单昭 博士生导师
Email: shanzhaolab@163.com
个人简介：
单昭，博士，研究员。实验室以药物性肝损伤（Drug Induced Liver Injury，DILI）和代谢功能障碍相关脂肪性肝病（Metabolic Dysfunction-Associated Steatotic Liver Disease，MASLD）小鼠模型为模型，聚焦肝脏疾病发病机制与治疗策略研究。其研究成果发表在Hepatology、eLife、PLOS Biology、Cell Reports、Nature Communications等主流期刊。主持国家自然基金面上项目、云南省“优秀青年”等项目。
2019.10-至今 伟德国际bevictor/中心，研究员，博导
2017.10-2019.7 休斯敦德克萨斯大学健康科学中心麦戈文医公司，博士后，导师：Cynthia Ju
2015.5-2017.9 科罗拉多大学药学系，安舒茨医公司，博士后，导师：Cynthia Ju
2009.9-2014.7 中科院上海巴斯德研究所, 博士，导师：李斌
2004.9-2009.6 吉林大学动物医学公司, 本科；
招生专业：
生物化学与分子生物学
生物与医药——生物化学与分子生物学
研究方向：
本课题组聚焦肝脏疾病发病机制与治疗策略研究，主要开展以下两个方向的工作：
1. 肝脏疾病免疫微环境调控研究
以药物性肝损伤（Drug Induced Liver Injury，DILI）和代谢功能障碍相关脂肪性肝病（Metabolic Dysfunction-Associated Steatotic Liver Disease，MASLD）小鼠模型为基础，系统研究肝脏微环境中各类细胞（特别是免疫细胞）及肠道微生物在肝脏疾病中的作用机理，探索急慢性肝损伤过程中的关键分子事件，旨在发现新型治疗靶点和微生物源治疗药物。
2. 溶酶体-脂代谢调控机制研究
基于秀丽隐杆线虫溶酶体响应型脂质代谢动态监测系统，通过整合遗传筛选（全基因组规模）和化合物筛选（高通量）双轨策略，系统鉴定调控溶酶体功能的关键基因和活性小分子。结合哺乳动物模型验证，深入解析溶酶体调控脂质代谢的分子机制，为脂肪肝、肥胖等代谢性疾病的治疗提供新靶点。
代表性研究成果：
论文（共同第一作者#，共同通讯作者*）：
入职1946伟德国际源自英国后，1946伟德国际源自英国为单位论文：
1. Jia Tie#, Lang Wang#, Xiong Wang#, Meng Tian, Weiju Lu, BIN QI*, Zhao Shan*. Microbial Peptidoglycan Engages Autophagy Receptor P62 to Induce Protective Mitophagy in the Liver. bioRxiv (2025) 2025.06.27.662070; https://doi.org/10.1101/2025.06.27.662070
2. Ruoxue Yang, Jinghua Liu, Kai Fu, Ting Wan, Yahui Li, Can Shen, Ling Yang, Keqin Wang, Zhao Shan. Platelets promote acute liver injury via extracellular vesicles-mediated Aldolase A. bioRxiv (2026). https://doi.org/10.64898/2026.03.05.709856 (under review at eLife)
3. Kenan Zhang#, Zihan Luo#, Yan Chen,Yan Li, Lang Wang, Yanan Liu, Ruizhi Yang, Qian Li, Jiahao Zhao, BIN QI*, Zhao Shan*. Microbial Tryptophan Metabolism Activates Host Lysosomal Activity to Facilitate Lipid Breakdown. PLOS Biology (2026) 10.1371/journal.pbio.3003685
4. Jia He, Ran Li, Cheng Xie, Xiane Zhu , Keqin Wang, Zhao Shan. Hyperactivated Glycolysis Drives Spatially-Patterned Kupffer Cell Depletion in MASLD. eLife (2025)
https://doi.org/10.7554/eLife.109206.1
5. Yaying Zhu#, Chengxiang Deng#, Bo Chen#, Jia He#, Yanan Liu, Cheng Peng* , Zhao Shan*. Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury. eLife , (2025) https://doi.org/10.7554/eLife.108646.1
6. Jia He, Bo Chen, Xiong Wang, Ruoxue Yang, Chengxiang Deng, Xiane Zhu, Keqin Wang, Lang Wang, Xiaokang Lu, Cheng Peng, Canpeng Li, Zhao Shan. Differential Regulation of Hepatic Macrophage Fate by Chi3l1 in MASLD. eLife, (2025) https://doi.org/10.7554/eLife.107023.1
7. Yan Chen#, Ruizhi Yang#, Bin Qi*, and Zhao Shan*. Peptidoglycan-Chi3l1 interaction shapes gut microbiota in intestinal mucus layer. eLife, (2024), https://elifesciences.org/articles/92994v1
8. Jia He; Chengxiang Deng; Leonard Krall; Zhao Shan; ScRNA-seq and ST-seq in liver research, Cell Regeneration, (2024), 12(1) https://doi.org/10.1186/s13619-022-00152-5
9. YongJuan He, Yunqing Zhang, Huijuan Xie, Zhao Shan*, Zongliu Hou*, BIN QI*The shutdown of food digestion due to ER homeostasis disruption acts as a protective mechanism in C. elegans. Nature Communications, (2025) .
https://www.nature.com/articles/s41467-025-63712-8
10. Yating Liu#, Guojing Tian#, Ziyi Wang, Junkang Zheng, Huimin Liu, Sucheng Zhu,
Zhao Shan*, Bin Qi* . Neuronal Detection Triggers Systemic Digestive Shutdown in Response to Adverse Food Sources. eLife (2025) 14:RP104028. https://doi.org/10.7554/eLife.104028.1
11. Yating Liu#, Qian Li#, Guojing Tian, Xinyi Zhou, Panpan Chen, Bo Chen, Zhao Shan*, Bin Qi* . Neuronal PRDX-2-Mediated ROS Signaling Regulates Food Digestion via Intestinal UPRmt Activation. Nature Communications (2024). https://doi.org/10.1038/s41467-024-55013-3
12. Huimin Liu#, Panpan Chen#, Xubo Yang#, FanRui Hao, Guojing Tian, Zhao Shan*, Bin Qi*. Probiotics-sensing mechanism in neurons that initiates gut mitochondrial surveillance for pathogen defense. Cell Reports (2024).
https://doi.org/10.1016/j.celrep.2024.115021
13. Shan, Zhao ; Li Leike; Atkins Constance Lynn; Wang Meng; Wen Yankai; Jeong Jongmin; Moreno Nicolas F; Feng Dechun; Gui Xun; Zhang Ningyan; Lee Chun Geun; Elias Jack Angel; Lee William; Gao Bin; Lam Fong Wilson; An Zhiqiang; Ju Cynthia; Chitinase 3-like-1 Contributes to Acetaminophen-induced Liver Injury by Promoting Hepatic Platelet Recruitment, eLife, (2021), 439034
14. Zhao Shan; Ju Cynthia ; Hepatic Macrophages in Liver Injury., Frontiers in immunology, (2020), 11(322)
15. Zhao Shan ; Ju Cynthia ; Hepatic macrophages in drug-induced liver injury., Liver Research, (2019), 3(3-4): 170-175
入职1946伟德国际源自英国前（2019年之前博后、研究生阶段论文）：
16. Zhao Shan ; Xiaodong Liu; Yuan Chen; Meng Wang; Yue Rachel Gao; Liangguo Xu; Wasim A. Dar; Chun Geun Lee; Jack Angel Elias; Pavel Davizon Castillo; Jorge Di Paola; Cynthia Ju ; Chitinase 3 -like-1 Promotes Intrahepatic Activation of Coagulation Through Induction of Tissue Factor in Mice, Hepatology, (2018), 67(6): 2384-2396
17. Shan Z, Alvarez-Sola G, Uriarte I, Arechederra M, Fernandez-Barrena MG, Berasain C, Ju C, Avila MA.. Fibroblast growth factors 19 and 21 in acute liver damage. Annals of Translational Medicine (2018), 6(12):257
18. Shan J#, Zhao B#, Shan Z#, Nie J, Deng R, Xiong R, Tsun A, Pan W, Zhao H, Chen L, Jin Y, Qian Z, Lui K, Liang R, Li D, Sun B, Lavillette D, Xu K, Li B. Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation. PLoS Pathog (2017), 13: e1006773 (*co-first author)
19. Shan Z, Han Q, Nie J, Cao X, Chen Z, Yin S, Gao Y, Lin F, Zhou X, Xu K, Fan H, Qian Z, Sun B, Zhong J, Li B, Tsun A. Negative regulation of interferon-induced transmembrane protein 3 by SET7-mediated lysine monomethylation. J Biol Chem (2013), 288: 35093-103
专利：
1. 一种肽聚糖在制备肝细胞线粒体自噬诱导剂中的应用（发明人：单昭, 祁斌, 铁佳, 王雄,王朗；申请号：2025107883827）
2. 一种大肠杆菌联合色氨酸在激活溶酶体功能中的应用（发明人：祁斌, 单昭, 张柯楠, 罗子涵；申请号：2025105939048）
